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Metabolism and Mass Balance in Rats Following Oral Administration of the Novel Antifibrotic Drug Fluorofenidone

OBJECTIVE: Fluorofenidone (AKF-PD) is a novel antifibrotic small-molecule compound. The purpose of this study was to investigate the metabolic and excretory pathways of AKF-PD in rats. METHODS: High-performance liquid chromatography with mass spectrometric (HPLC-MS) detection was used to analyze the...

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Detalles Bibliográficos
Autores principales: Wu, Wei, Cheng, Ze-neng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979420/
https://www.ncbi.nlm.nih.gov/pubmed/35386852
http://dx.doi.org/10.2147/DDDT.S346661