Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation

Hypophosphatasia (HPP) is a rare inherited disorder characterized by defective bone mineralization and is highly variable in its clinical phenotype. The disease occurs due to various loss-of-function mutations in ALPL, the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). In this work,...

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Detalles Bibliográficos
Autores principales: Xiao, Fei, Zhou, Ziyun, Song, Xingyu, Gan, Mi, Long, Jie, Verkhivker, Gennady, Hu, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979438/
https://www.ncbi.nlm.nih.gov/pubmed/35320273
http://dx.doi.org/10.1371/journal.pcbi.1010009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979438/
https://www.ncbi.nlm.nih.gov/pubmed/35320273
http://dx.doi.org/10.1371/journal.pcbi.1010009

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