Cargando…

The D2R-DISC1 protein complex and associated proteins are altered in schizophrenia and normalized with antipsychotic treatment

BACKGROUND: For decades, the dopamine D2 receptor (D2R) has been known as the main target of antipsychotic medications, but the mechanism for antipsychotic effects beyond this pharmacological target remains unclear. Disrupted-in-schizophrenia 1 (DISC1) is a gene implicated in the etiology of schizop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jijun, Su, Ping, Yang, Jian, Xu, Lihua, Yuan, Aihua, Li, Chunbo, Zhang, Tianhong, Dong, Fang, Zhou, Jingjing, Samsom, James, Wong, Albert H.C., Liu, Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	CMA Impact Inc. 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979657/ https://www.ncbi.nlm.nih.gov/pubmed/35361701 http://dx.doi.org/10.1503/jpn.210145

Ejemplares similares

Altered attentive bias towards interpersonal communication information across phases of schizophrenia: an eye-tracking study
por: Zhu, Yikang, et al.
Publicado: (2022)

Efficacy and safety of treating patients with refractory schizophrenia with antipsychotic medication and adjunctive electroconvulsive therapy: a systematic review and meta-analysis
por: WANG, Wenzheng, et al.
Publicado: (2015)

Schizophrenia Gene Expression Profile Reverted to Normal Levels by Antipsychotics
por: Crespo-Facorro, Benedicto, et al.
Publicado: (2015)

Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
por: Samsom, James N., et al.
Publicado: (2015)

25 Hz Magnetic Seizure Therapy Is Feasible but Not Optimal for Chinese Patients With Schizophrenia: A Case Series
por: Jiang, Jiangling, et al.
Publicado: (2018)

Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk
por: Wang, Junjie, et al.
Publicado: (2016)

Antipsychotic prescription, assumption and conversion to psychosis: resolving missing clinical links to optimize prevention through precision
por: Zhang, TianHong, et al.
Publicado: (2022)

S171. EFFECT OF DAOA GENETIC VARIATION ON WHITE MATTER ALTERATION IN CORPUS CALLOSUM IN PATIENTS WITH FIRST-EPISODE SCHIZOPHRENIA
por: Su, Wenjun, et al.
Publicado: (2020)

Alterations of Intrinsic Connectivity Networks in Antipsychotic-Naïve First-Episode Schizophrenia
por: Anhøj, Simon, et al.
Publicado: (2018)

Meta-analysis of cognitive function in Chinese first-episode schizophrenia: MATRICS Consensus Cognitive Battery (MCCB) profile of impairment
por: Zhang, Huijuan, et al.
Publicado: (2019)

Interactions of human truncated DISC1 proteins: implications for schizophrenia
por: Newburn, E N, et al.
Publicado: (2011)

DISC1-binding proteins in neural development, signalling and schizophrenia
por: Bradshaw, Nicholas J., et al.
Publicado: (2012)

Volume alteration of hippocampal subfields in first-episode antipsychotic-naïve schizophrenia patients before and after acute antipsychotic treatment
por: Li, Wenbin, et al.
Publicado: (2018)

Antipsychotic monotherapy and polypharmacy in the naturalistic treatment of schizophrenia with atypical antipsychotics
por: Faries, Douglas, et al.
Publicado: (2005)

Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review
por: Singh, Raghunath, et al.
Publicado: (2022)

Using aripiprazole to reduce antipsychotic-induced hyperprolactinemia: meta-analysis of currently available randomized controlled trials
por: MENG, Meiling, et al.
Publicado: (2015)

Comparison of Long-Acting Injectable Antipsychotics With Oral Antipsychotics and Suicide and All-Cause Mortality in Patients With Newly Diagnosed Schizophrenia
por: Huang, Cheng-Yi, et al.
Publicado: (2021)

Parietal memory network and default mode network in first‐episode drug‐naïve schizophrenia: Associations with auditory hallucination
por: Guo, Qian, et al.
Publicado: (2020)

Temporoparietal Connectivity Within Default Mode Network Associates With Clinical Improvements in Schizophrenia Following Modified Electroconvulsive Therapy
por: Hu, Qiang, et al.
Publicado: (2022)

Atypical Antipsychotics Mediate Dynamics of Intrinsic Brain Activity in Early-Stage Schizophrenia? A Preliminary Study
por: Wang, Yingchan, et al.
Publicado: (2021)

Psychosis risk syndrome is not prodromal psychosis
por: XU, Lihua, et al.
Publicado: (2015)

Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia
por: Kim, Jong-Hoon, et al.
Publicado: (2013)

Cost of antipsychotic polypharmacy in the treatment of schizophrenia
por: Zhu, Baojin, et al.
Publicado: (2008)

Comparative effectiveness of antipsychotic drugs in schizophrenia
por: Stroup, T. Scott, et al.
Publicado: (2000)

The heterogeneity of antipsychotic response in the treatment of schizophrenia
por: Case, M., et al.
Publicado: (2011)

New atypical antipsychotics for schizophrenia: iloperidone
por: Caccia, Silvio, et al.
Publicado: (2010)

Osteoporosis Associated with Antipsychotic Treatment in Schizophrenia
por: Wu, Haishan, et al.
Publicado: (2013)

Antipsychotic agents: efficacy and safety in schizophrenia
por: de Araújo, Arão Nogueira, et al.
Publicado: (2012)

Polypharmacy Management of Antipsychotics in Patients with Schizophrenia
por: Kamei, Hiroyuki
Publicado: (2022)

Altered expression of the DISC1 gene in peripheral blood of patients with schizophrenia
por: Fu, Xiaoqian, et al.
Publicado: (2020)

Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies
por: Korth, Carsten
Publicado: (2012)

Unresolved Issues for Utilization of Atypical Antipsychotics in Schizophrenia: Antipsychotic Polypharmacy and Metabolic Syndrome
por: Jeon, Sang Won, et al.
Publicado: (2017)

The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1
por: Bradshaw, Nicholas J.
Publicado: (2017)

Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia: A systematic review
por: Cui, Huiru, et al.
Publicado: (2012)

Calcium-binding proteins are altered in the cerebellum in schizophrenia
por: Vidal-Domènech, Francisco, et al.
Publicado: (2020)

Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia
por: Lei, Du, et al.
Publicado: (2022)

Real-World Effectiveness and Safety of Antipsychotics in Individuals at Clinical High-Risk for Psychosis: Study Protocol for a Prospective Observational Study (ShangHai at Risk for Psychosis-Phase 2)
por: Wu, GuiSen, et al.
Publicado: (2019)

R17C Mutation in Photoreceptor Disc-Specific Protein, PRCD, Results in Additional Lipidation Altering Protein Stability and Subcellular Localization
por: Myers, Boyden, et al.
Publicado: (2022)

Predictors of switching antipsychotic medications in the treatment of schizophrenia
por: Nyhuis, Allen W, et al.
Publicado: (2010)

Developments in antipsychotic therapy with regard to hypotheses for schizophrenia
por: Ackenheil, Manfred, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_k9m5nculi7b2qu4mvtn9qh655u