Exploring the Resistance Mechanisms of Distal D835V Mutation in FLT3 to Inhibitors

OBJECTIVE: FMS-like tyrosine kinase 3 (FLT3) is an attractive therapeutic target in acute myeloid leukemia. Unfortunately, secondary FLT3 mutations that developed resistance to inhibitors have become a severe problem. Specifically, ASP-835 (D835F/H/V/Y) mutant within the activation loop of FLT3 is t...

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Detalles Bibliográficos
Autores principales: Wang, Zhiwei, Hu, Baichun, An, Yu, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979743/
https://www.ncbi.nlm.nih.gov/pubmed/35387260
http://dx.doi.org/10.1155/2022/3720026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979743/
https://www.ncbi.nlm.nih.gov/pubmed/35387260
http://dx.doi.org/10.1155/2022/3720026

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