Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9

To investigate clonal hematopoiesis associated gene mutations in vitro and to unravel the direct impact on the human stem and progenitor cell (HSPC) compartment, we targeted healthy, young hematopoietic progenitor cells, derived from umbilical cord blood samples, with CRISPR/Cas9 technology. Site-sp...

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Detalles Bibliográficos
Autores principales: Christen, Friederike, Hablesreiter, Raphael, Hoyer, Kaja, Hennch, Cornelius, Maluck-Böttcher, Antje, Segler, Angela, Madadi, Annett, Frick, Mareike, Bullinger, Lars, Briest, Franziska, Damm, Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979818/
https://www.ncbi.nlm.nih.gov/pubmed/34782715
http://dx.doi.org/10.1038/s41375-021-01469-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979818/
https://www.ncbi.nlm.nih.gov/pubmed/34782715
http://dx.doi.org/10.1038/s41375-021-01469-x

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