Cargando…

Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9

To investigate clonal hematopoiesis associated gene mutations in vitro and to unravel the direct impact on the human stem and progenitor cell (HSPC) compartment, we targeted healthy, young hematopoietic progenitor cells, derived from umbilical cord blood samples, with CRISPR/Cas9 technology. Site-sp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Christen, Friederike, Hablesreiter, Raphael, Hoyer, Kaja, Hennch, Cornelius, Maluck-Böttcher, Antje, Segler, Angela, Madadi, Annett, Frick, Mareike, Bullinger, Lars, Briest, Franziska, Damm, Frederik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979818/ https://www.ncbi.nlm.nih.gov/pubmed/34782715 http://dx.doi.org/10.1038/s41375-021-01469-x

Ejemplares similares

Clonal hematopoiesis of indeterminate potential-related epigenetic age acceleration correlates with clonal hematopoiesis of indeterminate potential clone size in patients with high morbidity
por: Feldkamp, Jasper David, et al.
Publicado: (2022)

Single-cell analysis based dissection of clonality in myelofibrosis
por: Mylonas, Elena, et al.
Publicado: (2020)

Clonal hematopoiesis and its emerging effects on cellular therapies
por: von Bonin, Malte, et al.
Publicado: (2021)

Mechanisms of Resistance to Small Molecules in Acute Myeloid Leukemia
por: Lang, Tonio Johannes Lukas, et al.
Publicado: (2023)

Refining AML Treatment: The Role of Genetics in Response and Resistance Evaluation to New Agents
por: Halik, Adriane, et al.
Publicado: (2022)

Chipping in on clonal hematopoiesis
por: Gillis, Nancy K., et al.
Publicado: (2017)

Evolution of clonal hematopoiesis
por: van Zeventer, Isabelle A., et al.
Publicado: (2023)

A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial
por: Hoyer, K., et al.
Publicado: (2021)

Clinical Implications and Dynamics of Clonal Hematopoiesis in Anti-CD19 CAR T-cell Treated Patients
por: Panagiota, Victoria, et al.
Publicado: (2023)

Clonal Hematopoiesis and Vascular Disease
por: Amancherla, Kaushik, et al.
Publicado: (2022)

Discovering the drivers of clonal hematopoiesis
por: Pich, Oriol, et al.
Publicado: (2022)

Genetic Predisposition to Clonal Hematopoiesis
por: Quiros, Pedro M., et al.
Publicado: (2023)

Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma
por: Briest, Franziska, et al.
Publicado: (2023)

Aging of the Microenvironment Influences Clonality in Hematopoiesis
por: Vas, Virag, et al.
Publicado: (2012)

Clonal hematopoiesis in patients with rheumatoid arthritis
por: Savola, Paula, et al.
Publicado: (2018)

Clonal Hematopoiesis and Mutations of Myeloproliferative Neoplasms
por: Kjær, Lasse
Publicado: (2020)

CLONAL HEMATOPOIESIS IN A CENTENARIAN COHORT
por: Bhutkar, Aparna, et al.
Publicado: (2019)

Clonal hematopoiesis in sickle cell disease
por: Liggett, L. Alexander, et al.
Publicado: (2022)

Genetics of smoking and risk of clonal hematopoiesis
por: Levin, Michael G., et al.
Publicado: (2022)

Clonal hematopoiesis in primary immune thrombocytopenia
por: Wang, Yanming, et al.
Publicado: (2022)

Expanding approaches to detect clonal hematopoiesis
por: Khan, M.A. Wasay, et al.
Publicado: (2021)

Sex Differences in the Spectrum of Clonal Hematopoiesis
por: Kamphuis, Priscilla, et al.
Publicado: (2023)

Human Immunodeficiency Virus and Clonal Hematopoiesis
por: Vorri, Stamatia C., et al.
Publicado: (2023)

Clonal hematopoiesis in survivors of childhood cancer
por: Novetsky Friedman, Danielle, et al.
Publicado: (2023)

Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics
por: Uddin, Md Mesbah, et al.
Publicado: (2022)

Clonal analysis of lineage fate in native hematopoiesis
por: Rodriguez-Fraticelli, Alejo E., et al.
Publicado: (2018)

Clonal hematopoiesis and risk of acute myeloid leukemia
por: Young, Andrew L., et al.
Publicado: (2019)

Myelodysplasia Syndrome, Clonal Hematopoiesis and Cardiovascular Disease
por: Veiga, Camilla Bertuzzo, et al.
Publicado: (2021)

Clonal Hematopoiesis and Liquid Biopsy in Gastrointestinal Cancers
por: Croitoru, Vlad M., et al.
Publicado: (2022)

Measures of Clonal Hematopoiesis: Are We Missing Something?
por: Bystrykh, Leonid V., et al.
Publicado: (2022)

Compartment-specific mutational landscape of clonal hematopoiesis
por: Hartmann, Luise, et al.
Publicado: (2022)

Clonal hematopoiesis and cardiovascular disease: deciphering interconnections
por: Stein, Anna, et al.
Publicado: (2022)

Clonal Hematopoiesis and the Heart: a Toxic Relationship
por: Jensen, Jeffrey L., et al.
Publicado: (2023)

Obesity-induced inflammation exacerbates clonal hematopoiesis
por: Pasupuleti, Santhosh Kumar, et al.
Publicado: (2023)

Current Aspects of Clonal Hematopoiesis: Implications for Clinical Diagnosis
por: Karner, Kristin, et al.
Publicado: (2019)

Clonal Hematopoiesis in Hospitalized Elderly Patients With COVID-19
por: Hameister, Erik, et al.
Publicado: (2020)

Clonal Hematopoiesis, Cardiovascular Diseases and Hematopoietic Stem Cells
por: Kandarakov, Oleg, et al.
Publicado: (2020)

Cancer therapy shapes the fitness landscape of clonal hematopoiesis
por: Bolton, Kelly L, et al.
Publicado: (2020)

Author Correction: Clonal hematopoiesis in patients with rheumatoid arthritis
por: Savola, Paula, et al.
Publicado: (2021)

Employing the CRISPR-Cas System for Clonal Hematopoiesis Research
por: Ogawa, Hayato, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6q000lbcdhm6vp8t2lli55lmc5