SETD5 modulates homeostasis of hematopoietic stem cells by mediating RNA Polymerase II pausing in cooperation with HCF-1

SETD5 mutations were identified as the genetic causes of neurodevelopmental disorders. While the whole-body knockout of Setd5 in mice leads to embryonic lethality, the role of SETD5 in adult stem cell remains unexplored. Here, a critical role of Setd5 in hematopoietic stem cells (HSCs) is identified...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Mengke, Qiu, Chen, Bian, Yujie, Shi, Deyang, Wang, Bichen, Ma, Qiuyi, Wang, Xiaomin, Shi, Jun, Zhang, Lianfeng, Ma, Yuanwu, Zhu, Ping, Cheng, Tao, Chu, Yajing, Yuan, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979820/
https://www.ncbi.nlm.nih.gov/pubmed/34853439
http://dx.doi.org/10.1038/s41375-021-01481-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979820/
https://www.ncbi.nlm.nih.gov/pubmed/34853439
http://dx.doi.org/10.1038/s41375-021-01481-1

Ejemplares similares