miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+ CD8+ T large granular lymphocyte leukemia

T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of constitutive activation of the STAT3 and ERK pathway. Notably, in 40% of patients, constitutive STAT3 activation is due to STAT3 activating mutations, whereas in 60% this is unknown. As miRNAs...

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Detalles Bibliográficos
Autores principales: Assmann, Jorn L. J. C., Leon, Leticia G., Stavast, Christiaan J., van den Bogaerdt, Sanne E., Schilperoord-Vermeulen, Joyce, Sandberg, Yorick, Bellido, Mar, Erkeland, Stefan J., Feith, David J., Loughran Jr, Thomas P., Langerak, Anton W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979821/
https://www.ncbi.nlm.nih.gov/pubmed/34873301
http://dx.doi.org/10.1038/s41375-021-01480-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979821/
https://www.ncbi.nlm.nih.gov/pubmed/34873301
http://dx.doi.org/10.1038/s41375-021-01480-2

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