Synergistic activity of combined inhibition of anti-apoptotic molecules in B-cell precursor ALL

Targeting BCL-2, a key regulator of survival in B-cell malignancies including precursor B-cell acute lymphoblastic leukemia, has become a promising treatment strategy. However, given the redundancy of anti-apoptotic BCL-2 family proteins (BCL-2, BCL-XL, MCL-1), single targeting may not be sufficient...

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Detalles Bibliográficos
Autores principales: Seyfried, Felix, Stirnweiß, Felix Uli, Niedermayer, Alexandra, Enzenmüller, Stefanie, Hörl, Rebecca Louise, Münch, Vera, Köhrer, Stefan, Debatin, Klaus-Michael, Meyer, Lüder Hinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979822/
https://www.ncbi.nlm.nih.gov/pubmed/35031695
http://dx.doi.org/10.1038/s41375-021-01502-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979822/
https://www.ncbi.nlm.nih.gov/pubmed/35031695
http://dx.doi.org/10.1038/s41375-021-01502-z

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