MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers

Methylthioadenosine phosphorylase, an essential enzyme for the adenine salvage pathway, is often deficient (MTAP(def)) in tumors with 9p21 loss and hypothetically renders tumors susceptible to synthetic lethality by antifolates targeting de novo purine synthesis. Here we report our single arm phase...

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Detalles Bibliográficos
Autores principales: Alhalabi, Omar, Chen, Jianfeng, Zhang, Yuxue, Lu, Yang, Wang, Qi, Ramachandran, Sumankalai, Tidwell, Rebecca Slack, Han, Guangchun, Yan, Xinmiao, Meng, Jieru, Wang, Ruiping, Hoang, Anh G., Wang, Wei-Lien, Song, Jian, Lopez, Lidia, Andreev-Drakhlin, Alex, Siefker-Radtke, Arlene, Zhang, Xinqiao, Benedict, William F., Shah, Amishi Y., Wang, Jennifer, Msaouel, Pavlos, Zhang, Miao, Guo, Charles C., Czerniak, Bogdan, Behrens, Carmen, Soto, Luisa, Papadimitrakopoulou, Vassiliki, Lewis, Jeff, Rinsurongkawong, Waree, Rinsurongkawong, Vadeerat, Lee, Jack, Roth, Jack, Swisher, Stephen, Wistuba, Ignacio, Heymach, John, Wang, Jing, Campbell, Matthew T., Efstathiou, Eleni, Titus, Mark, Logothetis, Christopher J., Ho, Thai H., Zhang, Jianjun, Wang, Linghua, Gao, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980015/
https://www.ncbi.nlm.nih.gov/pubmed/35379845
http://dx.doi.org/10.1038/s41467-022-29397-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980015/
https://www.ncbi.nlm.nih.gov/pubmed/35379845
http://dx.doi.org/10.1038/s41467-022-29397-z

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