Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

Pancreatic ductal adenocarcinoma (PDA) is an inherently immune cell deprived tumor, characterized by desmoplastic stroma and suppressive immune cells. Here we systematically dissect PDA intrinsic mechanisms of immune evasion by in vitro and in vivo CRISPR screening, and identify Vps4b and Rnf31 as e...

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Detalles Bibliográficos
Autores principales: Frey, Nina, Tortola, Luigi, Egli, David, Janjuha, Sharan, Rothgangl, Tanja, Marquart, Kim Fabiano, Ampenberger, Franziska, Kopf, Manfred, Schwank, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980030/
https://www.ncbi.nlm.nih.gov/pubmed/35379808
http://dx.doi.org/10.1038/s41467-022-29412-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980030/
https://www.ncbi.nlm.nih.gov/pubmed/35379808
http://dx.doi.org/10.1038/s41467-022-29412-3

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