Auxiliary ATP binding sites support DNA unwinding by RecBCD

The RecBCD helicase initiates double-stranded break repair in bacteria by processively unwinding DNA with a rate approaching ∼1,600 bp·s(−1), but the mechanism enabling such a fast rate is unknown. Employing a wide range of methodologies — including equilibrium and time-resolved binding experiments,...

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Detalles Bibliográficos
Autores principales: Zananiri, Rani, Mangapuram Venkata, Sivasubramanyan, Gaydar, Vera, Yahalom, Dan, Malik, Omri, Rudnizky, Sergei, Kleifeld, Oded, Kaplan, Ariel, Henn, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980037/
https://www.ncbi.nlm.nih.gov/pubmed/35379800
http://dx.doi.org/10.1038/s41467-022-29387-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980037/
https://www.ncbi.nlm.nih.gov/pubmed/35379800
http://dx.doi.org/10.1038/s41467-022-29387-1

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