ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation

Moderate autophagy can remove damaged proteins and organelles. In some inflammatory diseases, autophagy plays a protective role by inhibiting the NOD-like receptor family pyrin domain containing 3(NLRP3). (Pro)renin receptor (PRR, or ATP6AP2) is a critical component of the V-ATPase required for auto...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Lei, Cui, Ya-juan, Liu, Yu, Li, Hui-xin, Su, Yu-dong, Li, Sheng-nan, Wang, Lan-lan, Zhao, Yue-wen, Wang, Shuang-xi, Yan, Feng, Dong, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980069/
https://www.ncbi.nlm.nih.gov/pubmed/35379787
http://dx.doi.org/10.1038/s41420-022-00967-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980069/
https://www.ncbi.nlm.nih.gov/pubmed/35379787
http://dx.doi.org/10.1038/s41420-022-00967-w

Ejemplares similares