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ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation

Moderate autophagy can remove damaged proteins and organelles. In some inflammatory diseases, autophagy plays a protective role by inhibiting the NOD-like receptor family pyrin domain containing 3(NLRP3). (Pro)renin receptor (PRR, or ATP6AP2) is a critical component of the V-ATPase required for auto...

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Detalles Bibliográficos
Autores principales:	Li, Lei, Cui, Ya-juan, Liu, Yu, Li, Hui-xin, Su, Yu-dong, Li, Sheng-nan, Wang, Lan-lan, Zhao, Yue-wen, Wang, Shuang-xi, Yan, Feng, Dong, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980069/ https://www.ncbi.nlm.nih.gov/pubmed/35379787 http://dx.doi.org/10.1038/s41420-022-00967-w

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