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Immunosuppression by piperine as a regulator of the NLRP3 inflammasome through MAPK/NF-κB in monosodium urate-induced rat gouty arthritis

BACKGROUND AND AIM: Gouty arthritis is a metabolic disorder involving monosodium urate (MSU) crystal deposition as a key initiator of acute inflammation. Dysregulation of the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome is...

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Detalles Bibliográficos
Autores principales: Jati, Galih Aji Kuncoro, Assihhah, Nazzun, Wati, Anas Ardiana, Salasia, Siti Isrina Oktavia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980401/
https://www.ncbi.nlm.nih.gov/pubmed/35400961
http://dx.doi.org/10.14202/vetworld.2022.288-298