Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal and eye diseases, respectively. Binding of solub...

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Detalles Bibliográficos
Autores principales: Papp, Alexandra, Papp, Krisztián, Uzonyi, Barbara, Cserhalmi, Marcell, Csincsi, Ádám I., Szabó, Zsóka, Bánlaki, Zsófia, Ermert, David, Prohászka, Zoltán, Erdei, Anna, Ferreira, Viviana P., Blom, Anna M., Józsi, Mihály
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980529/
https://www.ncbi.nlm.nih.gov/pubmed/35392081
http://dx.doi.org/10.3389/fimmu.2022.845953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980529/
https://www.ncbi.nlm.nih.gov/pubmed/35392081
http://dx.doi.org/10.3389/fimmu.2022.845953

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