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Catalytic Diastereo- and Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols through a Vinylogous Aldol Reaction of Alkylidenepyrazolones with Trifluoromethyl Ketones

[Image: see text] A diastereo- and enantioselective organocatalytic aldol reaction between alkylidenepyrazolones and trifluoromethyl ketones leading to chiral tertiary alcohols bearing a trifluoromethyl group is presented. The methodology is based on the use of a bifunctional organocatalyst in order...

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Detalles Bibliográficos
Autores principales:	Carceller-Ferrer, Laura, González del Campo, Aleix, Vila, Carlos, Blay, Gonzalo, Muñoz, M. Carmen, Pedro, José R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981347/ https://www.ncbi.nlm.nih.gov/pubmed/35293756 http://dx.doi.org/10.1021/acs.joc.1c02817

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