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Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses

The asymmetric total synthesis of four lignans, dimethylmatairesinol, matairesinol, (−)-niranthin, and (+)-niranthin has been achieved using reductive ring-opening of cyclopropanes. Moreover, we performed bioassays of the synthesized (+)- and (−)-niranthins using hepatitis B and influenza viruses, w...

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Detalles Bibliográficos
Autores principales: Ota, Ryotaro, Karasawa, Daichi, Oshima, Mizuki, Watashi, Koichi, Shimasaki, Noriko, Nishii, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981369/
https://www.ncbi.nlm.nih.gov/pubmed/35425482
http://dx.doi.org/10.1039/d2ra00499b