Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses

The asymmetric total synthesis of four lignans, dimethylmatairesinol, matairesinol, (−)-niranthin, and (+)-niranthin has been achieved using reductive ring-opening of cyclopropanes. Moreover, we performed bioassays of the synthesized (+)- and (−)-niranthins using hepatitis B and influenza viruses, w...

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Detalles Bibliográficos
Autores principales: Ota, Ryotaro, Karasawa, Daichi, Oshima, Mizuki, Watashi, Koichi, Shimasaki, Noriko, Nishii, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981369/
https://www.ncbi.nlm.nih.gov/pubmed/35425482
http://dx.doi.org/10.1039/d2ra00499b
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author Ota, Ryotaro
Karasawa, Daichi
Oshima, Mizuki
Watashi, Koichi
Shimasaki, Noriko
Nishii, Yoshinori
author_facet Ota, Ryotaro
Karasawa, Daichi
Oshima, Mizuki
Watashi, Koichi
Shimasaki, Noriko
Nishii, Yoshinori
author_sort Ota, Ryotaro
collection PubMed
description The asymmetric total synthesis of four lignans, dimethylmatairesinol, matairesinol, (−)-niranthin, and (+)-niranthin has been achieved using reductive ring-opening of cyclopropanes. Moreover, we performed bioassays of the synthesized (+)- and (−)-niranthins using hepatitis B and influenza viruses, which revealed the relationship between the enantiomeric structure and the anti-viral activity of niranthin.
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spelling pubmed-89813692022-04-13 Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses Ota, Ryotaro Karasawa, Daichi Oshima, Mizuki Watashi, Koichi Shimasaki, Noriko Nishii, Yoshinori RSC Adv Chemistry The asymmetric total synthesis of four lignans, dimethylmatairesinol, matairesinol, (−)-niranthin, and (+)-niranthin has been achieved using reductive ring-opening of cyclopropanes. Moreover, we performed bioassays of the synthesized (+)- and (−)-niranthins using hepatitis B and influenza viruses, which revealed the relationship between the enantiomeric structure and the anti-viral activity of niranthin. The Royal Society of Chemistry 2022-02-07 /pmc/articles/PMC8981369/ /pubmed/35425482 http://dx.doi.org/10.1039/d2ra00499b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Ota, Ryotaro
Karasawa, Daichi
Oshima, Mizuki
Watashi, Koichi
Shimasaki, Noriko
Nishii, Yoshinori
Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses
title Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses
title_full Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses
title_fullStr Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses
title_full_unstemmed Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses
title_short Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses
title_sort asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis b and influenza viruses
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981369/
https://www.ncbi.nlm.nih.gov/pubmed/35425482
http://dx.doi.org/10.1039/d2ra00499b
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