Inhibition of phosphodiesterase‐4 in the spinal dorsal horn ameliorates neuropathic pain via cAMP‐cytokine‐Cx43 signaling in mice

BACKGROUND: The spinal phosphodiesterase‐4 (PDE4) plays an important role in chronic pain. Inhibition of PDE4, an enzyme catalyzing the hydrolysis of cyclic adenosine monophosphate AMP (cAMP), produces potent antinociceptive activity. However, the antinociceptive mechanism remains largely unknown. C...

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Detalles Bibliográficos
Autores principales: Zhang, Fang‐fang, Wang, Hao, Zhou, Yan‐meng, Yu, Hai‐yang, Zhang, Melanie, Du, Xian, Wang, Dong, Zhang, Feng, Xu, Ying, Zhang, Ji‐guo, Zhang, Han‐Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981432/
https://www.ncbi.nlm.nih.gov/pubmed/35156776
http://dx.doi.org/10.1111/cns.13807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981432/
https://www.ncbi.nlm.nih.gov/pubmed/35156776
http://dx.doi.org/10.1111/cns.13807

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