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The effect of propofol on hypoxia‐ and TNF‐α‐mediated BDNF/TrkB pathway dysregulation in primary rat hippocampal neurons

AIMS: Hypoxia and inflammation may lead to BDNF/TrkB dysregulation and neurological disorders. Propofol is an anesthetic with neuroprotective properties. We wondered whether and how propofol affected BDNF/TrkB pathway in hippocampal neurons and astrocytes. METHODS: Primary rat hippocampal neurons an...

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Detalles Bibliográficos
Autores principales: Tao, Weiping, Zhang, Xuesong, Ding, Juan, Yu, Shijian, Ge, Peiqing, Han, Jingfeng, Luo, Xing, Cui, Wei, Chen, Jiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981449/
https://www.ncbi.nlm.nih.gov/pubmed/35112804
http://dx.doi.org/10.1111/cns.13809