TAP dysfunction in dendritic cells enables non-canonical cross-presentation for T cell priming

Classic MHC-I presentation relies on shuttling cytosolic peptides into the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). Viruses disable TAP to block MHC-I presentation and evade cytotoxic CD8(+) T cells. Priming CD8(+) T cells against these viruses is thoug...

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Detalles Bibliográficos
Autores principales: Barbet, Gaëtan, Nair-Gupta, Priyanka, Schotsaert, Michael, Yeung, Stephen T., Moretti, Julien, Seyffer, Fabian, Metreveli, Giorgi, Gardner, Thomas, Choi, Angela, Tortorella, Domenico, Tampé, Robert, Khanna, Kamal M., García-Sastre, Adolfo, Blander, J. Magarian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981674/
https://www.ncbi.nlm.nih.gov/pubmed/33790474
http://dx.doi.org/10.1038/s41590-021-00903-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981674/
https://www.ncbi.nlm.nih.gov/pubmed/33790474
http://dx.doi.org/10.1038/s41590-021-00903-7

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