A novel LC-MS/MS method for simultaneous estimation of acalabrutinib and its active metabolite acalabrutinib M(27) in human plasma and application to a human pharmacokinetic study

A simple, specific, selective and accurate bioanalytical method was developed and validated for simultaneous estimation of acalabrutinib and its active metabolite in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Deuterated analogs of both the analytes were used as int...

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Detalles Bibliográficos
Autores principales: Valluri, Venkat Rao, Katari, Naresh Kumar, Khatri, Chirag, Kasar, Pankaj, Polagani, Srinivasa Rao, Jonnalagadda, Sreekanth Babu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982068/
https://www.ncbi.nlm.nih.gov/pubmed/35424612
http://dx.doi.org/10.1039/d1ra09026g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982068/
https://www.ncbi.nlm.nih.gov/pubmed/35424612
http://dx.doi.org/10.1039/d1ra09026g

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