Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

HIV-1 clade C envelope immunogens that elicit both neutralizing and non-neutralizing V1V2-scaffold-specific antibodies (protective correlates from RV144 human trial) are urgently needed due to the prevalence of this clade in the most impacted regions worldwide. To achieve this, we introduce structur...

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Detalles Bibliográficos
Autores principales: Sahoo, Anusmita, Hodge, Edgar A., LaBranche, Celia C., Styles, Tiffany M., Shen, Xiaoying, Cheedarla, Narayanaiah, Shiferaw, Ayalnesh, Ozorowski, Gabriel, Lee, Wen-Hsin, Ward, Andrew B., Tomaras, Georgia D., Montefiori, David C., Irvine, Darrell J., Lee, Kelly K., Amara, Rama Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982139/
https://www.ncbi.nlm.nih.gov/pubmed/35235790
http://dx.doi.org/10.1016/j.celrep.2022.110436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982139/
https://www.ncbi.nlm.nih.gov/pubmed/35235790
http://dx.doi.org/10.1016/j.celrep.2022.110436

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