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Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

HIV-1 clade C envelope immunogens that elicit both neutralizing and non-neutralizing V1V2-scaffold-specific antibodies (protective correlates from RV144 human trial) are urgently needed due to the prevalence of this clade in the most impacted regions worldwide. To achieve this, we introduce structur...

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Detalles Bibliográficos
Autores principales:	Sahoo, Anusmita, Hodge, Edgar A., LaBranche, Celia C., Styles, Tiffany M., Shen, Xiaoying, Cheedarla, Narayanaiah, Shiferaw, Ayalnesh, Ozorowski, Gabriel, Lee, Wen-Hsin, Ward, Andrew B., Tomaras, Georgia D., Montefiori, David C., Irvine, Darrell J., Lee, Kelly K., Amara, Rama Rao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982139/ https://www.ncbi.nlm.nih.gov/pubmed/35235790 http://dx.doi.org/10.1016/j.celrep.2022.110436

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