Pan-cancer Analysis of Homologous Recombination Repair–associated Gene Alterations and Genome-wide Loss-of-Heterozygosity Score

PURPOSE: To study associations across tumor types between genome-wide loss of heterozygosity (gLOH) and alterations in homologous recombination repair (HRR)-associated genes beyond BRCA1 and BRCA2. EXPERIMENTAL DESIGN: Genomic profiling using a targeted next-generation sequencing assay examining 324...

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Detalles Bibliográficos
Autores principales: Westphalen, C. Benedikt, Fine, Alexander D., André, Fabrice, Ganesan, Shridar, Heinemann, Volker, Rouleau, Etienne, Turnbull, Clare, Garcia Palacios, Luis, Lopez, Jorge-Antonio, Sokol, Ethan S., Mateo, Joaquin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982267/
https://www.ncbi.nlm.nih.gov/pubmed/34740923
http://dx.doi.org/10.1158/1078-0432.CCR-21-2096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982267/
https://www.ncbi.nlm.nih.gov/pubmed/34740923
http://dx.doi.org/10.1158/1078-0432.CCR-21-2096

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