BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism

BACKGROUND: Heart failure (HF) is one of the leading causes of death worldwide and is associated with cardiac metabolic perturbations. Human Type 2 Berardinelli‐Seip Congenital Lipodystrophy (BSCL2) disease is caused by mutations in the BSCL2 gene. Global lipodystrophic Bscl2(−/−) mice exhibit hyper...

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Detalles Bibliográficos
Autores principales: Zhou, Hongyi, Li, Jie, Su, Huabo, Li, Ji, Lydic, Todd A., Young, Martin E, Chen, Weiqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982503/
https://www.ncbi.nlm.nih.gov/pubmed/35384404
http://dx.doi.org/10.1002/ctm2.736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982503/
https://www.ncbi.nlm.nih.gov/pubmed/35384404
http://dx.doi.org/10.1002/ctm2.736

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