Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance

The ongoing COVID‐19 pandemic represents an unprecedented global health crisis. Here, we report the identification of a synthetic nanobody (sybody) pair, Sb#15 and Sb#68, that can bind simultaneously to the SARS‐CoV‐2 spike RBD and efficiently neutralize pseudotyped and live viruses by interfering w...

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Detalles Bibliográficos
Autores principales: Walter, Justin D, Scherer, Melanie, Hutter, Cedric A J, Garaeva, Alisa A, Zimmermann, Iwan, Wyss, Marianne, Rheinberger, Jan, Ruedin, Yelena, Earp, Jennifer C, Egloff, Pascal, Sorgenfrei, Michèle, Hürlimann, Lea M, Gonda, Imre, Meier, Gianmarco, Remm, Sille, Thavarasah, Sujani, van Geest, Geert, Bruggmann, Rémy, Zimmer, Gert, Slotboom, Dirk J, Paulino, Cristina, Plattet, Philippe, Seeger, Markus A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982573/
https://www.ncbi.nlm.nih.gov/pubmed/35253970
http://dx.doi.org/10.15252/embr.202154199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982573/
https://www.ncbi.nlm.nih.gov/pubmed/35253970
http://dx.doi.org/10.15252/embr.202154199

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