The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation

While PAX5 is an important tumor suppressor gene in B‐cell acute lymphoblastic leukemia (B‐ALL), it is also involved in oncogenic translocations coding for diverse PAX5 fusion proteins. PAX5‐JAK2 encodes a protein consisting of the PAX5 DNA‐binding region fused to the constitutively active JAK2 kina...

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Detalles Bibliográficos
Autores principales: Jurado, Sabine, Fedl, Anna S, Jaritz, Markus, Kostanova‐Poliakova, Daniela, Malin, Stephen G, Mullighan, Charles G, Strehl, Sabine, Fischer, Maria, Busslinger, Meinrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982625/
https://www.ncbi.nlm.nih.gov/pubmed/35156727
http://dx.doi.org/10.15252/embj.2021108397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982625/
https://www.ncbi.nlm.nih.gov/pubmed/35156727
http://dx.doi.org/10.15252/embj.2021108397

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