Structural dynamics of receptor recognition and pH-induced dissociation of full-length Clostridioides difficile Toxin B

Clostridioides difficile secretes Toxin B (TcdB) as one of its major virulence factors, which binds to intestinal epithelial and subepithelial receptors, including frizzled proteins and chondroitin sulfate proteoglycan 4 (CSPG4). Here, we present cryo-EM structures of full-length TcdB in complex wit...

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Detalles Bibliográficos
Autores principales: Jiang, Mengqiu, Shin, Joonyoung, Simeon, Rudo, Chang, Jeng-Yih, Meng, Ran, Wang, Yuhang, Shinde, Omkar, Li, Pingwei, Chen, Zhilei, Zhang, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982864/
https://www.ncbi.nlm.nih.gov/pubmed/35324891
http://dx.doi.org/10.1371/journal.pbio.3001589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982864/
https://www.ncbi.nlm.nih.gov/pubmed/35324891
http://dx.doi.org/10.1371/journal.pbio.3001589

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