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An ensemble of parameters from a robust Markov-based model reproduces L-type calcium currents from different human cardiac myocytes

The development of modeling structures at the channel level that can integrate subcellular and cell models and properly reproduce different experimental data is of utmost importance in cardiac electrophysiology. In contrast to gate-based models, Markov Chain models are well suited to promote the int...

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Detalles Bibliográficos
Autores principales: Novaes, Gustavo Montes, Alvarez-Lacalle, Enrique, Muñoz, Sergio Alonso, dos Santos, Rodrigo Weber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982880/
https://www.ncbi.nlm.nih.gov/pubmed/35381041
http://dx.doi.org/10.1371/journal.pone.0266233