Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used quantitative imaging to track dynamic changes in end...

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Detalles Bibliográficos
Autores principales: Koch, Alex A, Bagnall, James S, Smyllie, Nicola J, Begley, Nicola, Adamson, Antony D, Fribourgh, Jennifer L, Spiller, David G, Meng, Qing-Jun, Partch, Carrie L, Strimmer, Korbinian, House, Thomas A, Hastings, Michael H, Loudon, Andrew SI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983044/
https://www.ncbi.nlm.nih.gov/pubmed/35285799
http://dx.doi.org/10.7554/eLife.73976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983044/
https://www.ncbi.nlm.nih.gov/pubmed/35285799
http://dx.doi.org/10.7554/eLife.73976

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