Increased Ca(2+) influx through Ca(V)1.2 drives aortic valve calcification

Calcific aortic valve disease (CAVD) is heritable, as revealed by recent GWAS. While polymorphisms linked to increased expression of CACNA1C — encoding the Ca(V)1.2 L-type voltage-gated Ca(2+) channel — and increased Ca(2+) signaling are associated with CAVD, whether increased Ca(2+) influx through...

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Detalles Bibliográficos
Autores principales: Matsui, Maiko, Bouchareb, Rihab, Storto, Mara, Hussain, Yasin, Gregg, Andrew, Marx, Steven O., Pitt, Geoffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983132/
https://www.ncbi.nlm.nih.gov/pubmed/35104251
http://dx.doi.org/10.1172/jci.insight.155569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983132/
https://www.ncbi.nlm.nih.gov/pubmed/35104251
http://dx.doi.org/10.1172/jci.insight.155569

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