Cargando…

Increased Ca(2+) influx through Ca(V)1.2 drives aortic valve calcification

Calcific aortic valve disease (CAVD) is heritable, as revealed by recent GWAS. While polymorphisms linked to increased expression of CACNA1C — encoding the Ca(V)1.2 L-type voltage-gated Ca(2+) channel — and increased Ca(2+) signaling are associated with CAVD, whether increased Ca(2+) influx through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matsui, Maiko, Bouchareb, Rihab, Storto, Mara, Hussain, Yasin, Gregg, Andrew, Marx, Steven O., Pitt, Geoffrey S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983132/ https://www.ncbi.nlm.nih.gov/pubmed/35104251 http://dx.doi.org/10.1172/jci.insight.155569

Ejemplares similares

Innate and Adaptive Immunity in Calcific Aortic Valve Disease
por: Mathieu, Patrick, et al.
Publicado: (2015)

STIMulating Ca(2+) influx
por: LeBrasseur, Nicole
Publicado: (2006)

Ca(2+) Influx in T Cells: How Many Ca(2+) Channels?
por: Feske, Stefan
Publicado: (2013)

Purinergic-mediated Ca(2+) influx in Dictyostelium discoideum
por: Ludlow, Melanie J., et al.
Publicado: (2008)

Inhibiting the Ca(2+) Influx Induced by Human CSF
por: Drews, Anna, et al.
Publicado: (2017)

Safranal Induces Vasorelaxation by Inhibiting Ca(2+) Influx and Na(+)/Ca(2+) Exchanger in Isolated Rat Aortic Rings
por: Al-Saigh, Noor Nadhim, et al.
Publicado: (2022)

Ca2+ influx activated by low pH in Chlamydomonas
Publicado: (1996)

Astrocyte Ca(2+) Influx Negatively Regulates Neuronal Activity
por: Zhang, Yao V., et al.
Publicado: (2017)

Orchestrating Ca(2+) influx through Ca(V)1.2 and Ca(V)3.x channels in human cerebral arteries
por: Collier, Daniel M., et al.
Publicado: (2015)

Reduced Loading of Intracellular Ca(2+) Stores and Downregulation of Capacitative Ca(2+)Influx in Bcl-2–Overexpressing Cells
por: Pinton, Paolo, et al.
Publicado: (2000)

Selectivity of the Ca binding site in synaptosome Ca channels. Inhibition of Ca influx by multivalent metal cations
Publicado: (1984)

Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors
Publicado: (1994)

T Cells of Infants Are Mature, but Hyporeactive Due to Limited Ca(2+) Influx
por: Schmiedeberg, Kristin, et al.
Publicado: (2016)

Mitochondrial Ca(2+) Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy
por: Xie, An, et al.
Publicado: (2018)

The contractile vacuole in Ca(2+)-regulation in Dictyostelium: its essential function for cAMP-induced Ca(2+)-influx
por: Malchow, Dieter, et al.
Publicado: (2006)

Ca(2+) influx–independent synaptic potentiation mediated by mitochondrial Na(+)-Ca(2+) exchanger and protein kinase C
por: Yang, Feng, et al.
Publicado: (2003)

Na(+)-induced Ca(2+) influx through reverse mode of Na(+)-Ca(2+) exchanger in mouse ventricular cardiomyocyte
por: Yan, Zhen-Yu, et al.
Publicado: (2015)

Ca(2+) influx and the store-operated Ca(2+) entry pathway undergo regulation during mouse oocyte maturation
por: Cheon, Banyoon, et al.
Publicado: (2013)

Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca(2+) release and Ca(2+) influx
por: Kilpatrick, Bethan S., et al.
Publicado: (2016)

Neuronal input triggers Ca(2+) influx through AMPA receptors and voltage‐gated Ca(2+) channels in oligodendrocytes
por: Barron, Tara, et al.
Publicado: (2019)

Aldosterone-Induced Sarco/Endoplasmic Reticulum Ca(2+) Pump Upregulation Counterbalances Ca(v)1.2-Mediated Ca(2+) Influx in Mesenteric Arteries
por: Salazar-Enciso, Rogelio, et al.
Publicado: (2022)

Cinnamomi ramulus Ethanol Extract Exerts Vasorelaxation through Inhibition of Ca(2+) Influx and Ca(2+) Release in Rat Aorta
por: Kang, Yun Hwan, et al.
Publicado: (2012)

Molecular identities of mitochondrial Ca(2+) influx mechanism: Updated passwords for accessing mitochondrial Ca(2+)-linked health and disease
por: O-Uchi, Jin, et al.
Publicado: (2012)

Intracellular Ca(2+) Stores and Ca(2+) Influx Are Both Required for BDNF to Rapidly Increase Quantal Vesicular Transmitter Release
por: Amaral, Michelle D., et al.
Publicado: (2012)

Ca2+ influx pathways mediated by swelling or stores depletion in mouse thymocytes
Publicado: (1995)

Ca2+ influx and neurite growth in response to purified N-cadherin and laminin
Publicado: (1994)

The role of Ca(2+) influx in endocytic vacuole formation in pancreatic acinar cells
por: Voronina, Svetlana, et al.
Publicado: (2015)

Ultrasensitive Measurement of Ca(2+) Influx into Lipid Vesicles Induced by Protein Aggregates
por: Flagmeier, Patrick, et al.
Publicado: (2017)

Developmental Axon Degeneration Requires TRPV1-Dependent Ca(2+) Influx
por: Johnstone, Aaron D., et al.
Publicado: (2019)

Control of Ca(2+) Influx and Calmodulin Activation by SK-Channels in Dendritic Spines
por: Griffith, Thom, et al.
Publicado: (2016)

Adhesion to oviduct glycans regulates porcine sperm Ca(2+) influx and viability
por: Machado, Sergio A., et al.
Publicado: (2020)

Functional expression of TRPM7 as a Ca(2+) influx pathway in adipocytes
por: Inoue, Hana, et al.
Publicado: (2019)

Ca(2+) Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes
por: Chen, Gui-Lan, et al.
Publicado: (2023)

Enhanced Ca(2+) influx through cardiac L-type Ca(2+) channels maintains the systolic Ca(2+) transient in early cardiac atrophy induced by mechanical unloading
por: Schwoerer, A. P., et al.
Publicado: (2013)

Excitation-Contraction Coupling in Zebrafish Ventricular Myocardium Is Regulated by Trans-Sarcolemmal Ca(2+) Influx and Sarcoplasmic Reticulum Ca(2+) Release
por: Haustein, Moritz, et al.
Publicado: (2015)

Differential regulation of nimodipine-sensitive and -insensitive Ca(2+) influx by the Na(+)/Ca(2+) exchanger and mitochondria in the rat suprachiasmatic nucleus neurons
por: Cheng, Pi-Cheng, et al.
Publicado: (2018)

Boron Deficiency Increases Cytosolic Ca(2+) Levels Mainly via Ca(2+) Influx from the Apoplast in Arabidopsis thaliana Roots
por: Quiles-Pando, Carlos, et al.
Publicado: (2019)

Blockage of Store-Operated Ca(2+) Influx by Synta66 is Mediated by Direct Inhibition of the Ca(2+) Selective Orai1 Pore
por: Waldherr, Linda, et al.
Publicado: (2020)

Interaction of background Ca(2+) influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca(2+) waves in sheep heart
por: Hutchings, David C., et al.
Publicado: (2022)

2-ns Electrostimulation of Ca(2+) Influx into Chromaffin Cells: Rapid Modulation by Field Reversal
por: Zaklit, Josette, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_plio0qlbj4kqsqt6p5kk27h6ff