Leukocytes mediate disease pathogenesis in the Ndufs4(KO) mouse model of Leigh syndrome

Symmetric, progressive, necrotizing lesions in the brainstem are a defining feature of Leigh syndrome (LS). A mechanistic understanding of the pathogenesis of these lesions has been elusive. Here, we report that leukocyte proliferation is causally involved in the pathogenesis of LS. Depleting leukoc...

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Detalles Bibliográficos
Autores principales: Stokes, Julia C., Bornstein, Rebecca L., James, Katerina, Park, Kyung Yeon, Spencer, Kira A., Vo, Katie, Snell, John C., Johnson, Brittany M., Morgan, Philip G., Sedensky, Margaret M., Baertsch, Nathan A., Johnson, Simon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983133/
https://www.ncbi.nlm.nih.gov/pubmed/35050903
http://dx.doi.org/10.1172/jci.insight.156522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983133/
https://www.ncbi.nlm.nih.gov/pubmed/35050903
http://dx.doi.org/10.1172/jci.insight.156522

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