IFN-α blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health

Type I IFNs (TI-IFNs) drive immune effector functions during acute viral infections and regulate cell cycling and systemic metabolism. That said, chronic TI-IFN signaling in the context of HIV infection treated with antiretroviral therapy (ART) also facilitates viral persistence, in part by promotin...

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Detalles Bibliográficos
Autores principales: Swainson, Louise A., Sharma, Ashish Arunkumar, Ghneim, Khader, Ribeiro, Susan Pereira, Wilkinson, Peter, Dunham, Richard M., Albright, Rebecca G., Wong, Samson, Estes, Jacob D., Piatak, Michael, Deeks, Steven G., Hunt, Peter W., Sekaly, Rafick-Pierre, McCune, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983135/
https://www.ncbi.nlm.nih.gov/pubmed/35104248
http://dx.doi.org/10.1172/jci.insight.153046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983135/
https://www.ncbi.nlm.nih.gov/pubmed/35104248
http://dx.doi.org/10.1172/jci.insight.153046

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