Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress

Pancreatic islets respond to metabolic and inflammatory stress by producing hormones and other factors that induce adaptive cellular and systemic responses. Here we show that intracellular Ca(2+) ([Ca(2+)](i)) and ROS signals generated by high glucose and cytokine-induced ER stress activate calcineu...

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Detalles Bibliográficos
Autores principales: Darden, Carly M., Vasu, Srividya, Mattke, Jordan, Liu, Yang, Rhodes, Christopher J., Naziruddin, Bashoo, Lawrence, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983383/
https://www.ncbi.nlm.nih.gov/pubmed/35402865
http://dx.doi.org/10.1016/j.isci.2022.104125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983383/
https://www.ncbi.nlm.nih.gov/pubmed/35402865
http://dx.doi.org/10.1016/j.isci.2022.104125

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