Cargando…
Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress
Pancreatic islets respond to metabolic and inflammatory stress by producing hormones and other factors that induce adaptive cellular and systemic responses. Here we show that intracellular Ca(2+) ([Ca(2+)](i)) and ROS signals generated by high glucose and cytokine-induced ER stress activate calcineu...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983383/ https://www.ncbi.nlm.nih.gov/pubmed/35402865 http://dx.doi.org/10.1016/j.isci.2022.104125 |