MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases

Mitochondria can function as signaling organelles, and part of this output leads to epigenetic remodeling. The full extent of this far-reaching interplay remains undefined. Here, we show that MYC transcriptionally activates IDH2 and increases alpha-ketoglutarate (αKG) levels. This regulatory step in...

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Detalles Bibliográficos
Autores principales: Lin, An-Ping, Qiu, Zhijun, Ethiraj, Purushoth, Sasi, Binu, Jaafar, Carine, Rakheja, Dinesh, Aguiar, Ricardo C. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983447/
https://www.ncbi.nlm.nih.gov/pubmed/34997181
http://dx.doi.org/10.1038/s41375-021-01489-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983447/
https://www.ncbi.nlm.nih.gov/pubmed/34997181
http://dx.doi.org/10.1038/s41375-021-01489-7

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