Small-Molecule NSC59984 Induces Mutant p53 Degradation through a ROS-ERK2-MDM2 Axis in Cancer Cells

Increased reactive oxygen species (ROS) and hyperstabilized mutant p53 are common in cancer. Hyperstabilized mutant p53 contributes to its gain of function (GOF) which confers resistance to chemotherapy and radiotherapy. Targeting mutant p53 degradation is a promising cancer therapeutic strategy. We...

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Detalles Bibliográficos
Autores principales: Zhang, Shengliang, Zhou, Lanlan, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Signal Transduction and Functional Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983457/
https://www.ncbi.nlm.nih.gov/pubmed/34992144
http://dx.doi.org/10.1158/1541-7786.MCR-21-0149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983457/
https://www.ncbi.nlm.nih.gov/pubmed/34992144
http://dx.doi.org/10.1158/1541-7786.MCR-21-0149

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