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A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation
The RAS GTPases are frequently mutated in human cancer, with KRAS being the predominant tumor driver. For many years, it has been known that the structure and function of RAS are integrally linked, as structural changes induced by GTP binding or mutational events determine the ability of RAS to inte...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Association for Cancer Research
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983508/ https://www.ncbi.nlm.nih.gov/pubmed/35046094 http://dx.doi.org/10.1158/2159-8290.CD-21-1494 |