Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition

Presequence protease (PreP), a 117 kDa mitochondrial M16C metalloprotease vital for mitochondrial proteostasis, degrades presequence peptides cleaved off from nuclear-encoded proteins and other aggregation-prone peptides, such as amyloid β (Aβ). PreP structures have only been determined in a closed...

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Detalles Bibliográficos
Autores principales: Liang, Wenguang G., Wijaya, Juwina, Wei, Hui, Noble, Alex J., Mancl, Jordan M., Mo, Swansea, Lee, David, Lin King, John V., Pan, Man, Liu, Chang, Koehler, Carla M., Zhao, Minglei, Potter, Clinton S., Carragher, Bridget, Li, Sheng, Tang, Wei-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983764/
https://www.ncbi.nlm.nih.gov/pubmed/35383169
http://dx.doi.org/10.1038/s41467-022-29322-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983764/
https://www.ncbi.nlm.nih.gov/pubmed/35383169
http://dx.doi.org/10.1038/s41467-022-29322-4

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