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Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition
Presequence protease (PreP), a 117 kDa mitochondrial M16C metalloprotease vital for mitochondrial proteostasis, degrades presequence peptides cleaved off from nuclear-encoded proteins and other aggregation-prone peptides, such as amyloid β (Aβ). PreP structures have only been determined in a closed...
Autores principales: | Liang, Wenguang G., Wijaya, Juwina, Wei, Hui, Noble, Alex J., Mancl, Jordan M., Mo, Swansea, Lee, David, Lin King, John V., Pan, Man, Liu, Chang, Koehler, Carla M., Zhao, Minglei, Potter, Clinton S., Carragher, Bridget, Li, Sheng, Tang, Wei-Jen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983764/ https://www.ncbi.nlm.nih.gov/pubmed/35383169 http://dx.doi.org/10.1038/s41467-022-29322-4 |
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