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A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential

INTRODUCTION: The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. METHODS: Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic mouse model—to investigate T14, a 14mer peptide, as a...

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Detalles Bibliográficos
Autores principales: Greenfield, Susan A., Cole, Gregory M., Coen, Clive W., Frautschy, Sally, Singh, Ram P., Mekkittikul, Marisa, Garcia‐Ratés, Sara, Morrill, Paul, Hollings, Owen, Passmore, Matt, Hasan, Sibah, Carty, Nikisha, Bison, Silvia, Piccoli, Laura, Carletti, Renzo, Tacconi, Stephano, Chalidou, Anna, Pedercini, Matthew, Kroecher, Tim, Astner, Hubert, Gerrard, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983808/
https://www.ncbi.nlm.nih.gov/pubmed/35415206
http://dx.doi.org/10.1002/trc2.12274