C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response

Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs). However, it remains unknown how PR poly-dipeptides affect cytoskeletal organization and focal adhesion (FA) formation. Here, we show that changes to the cytoskel...

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Detalles Bibliográficos
Autores principales: Shiota, Tomo, Nagata, Riko, Kikuchi, Sotaro, Nanaura, Hitoki, Matsubayashi, Masaya, Nakanishi, Mari, Kobashigawa, Shinko, Isozumi, Noriyoshi, Kiriyama, Takao, Nagayama, Kazuaki, Sugie, Kazuma, Yamashiro, Yoshito, Mori, Eiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983821/
https://www.ncbi.nlm.nih.gov/pubmed/35399536
http://dx.doi.org/10.3389/fcell.2022.750829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983821/
https://www.ncbi.nlm.nih.gov/pubmed/35399536
http://dx.doi.org/10.3389/fcell.2022.750829

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