IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse

PURPOSE: To investigate IL-17 related mechanisms for developing dry eye disease in the Pinkie mouse strain with a loss of function RXRα mutation. METHODS: Measures of dry eye disease were assessed in the cornea and conjunctiva. Expression profiling was performed by single-cell RNA sequencing (scRNA-...

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Detalles Bibliográficos
Autores principales: Alam, Jehan, Yazdanpanah, Ghasem, Ratnapriya, Rinki, Borcherding, Nicholas, de Paiva, Cintia S., Li, DeQuan, Guimaraes de Souza, Rodrigo, Yu, Zhiyuan, Pflugfelder, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983848/
https://www.ncbi.nlm.nih.gov/pubmed/35402439
http://dx.doi.org/10.3389/fmed.2022.849990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983848/
https://www.ncbi.nlm.nih.gov/pubmed/35402439
http://dx.doi.org/10.3389/fmed.2022.849990

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