A Novel N-Arylpyridone Compound Alleviates the Inflammatory and Fibrotic Reaction of Silicosis by Inhibiting the ASK1-p38 Pathway and Regulating Macrophage Polarization

Silicosis is one of the potentially fatal occupational diseases characterized by respiratory dysfunction, chronic interstitial inflammation, and fibrosis, for which treatment options are limited. Previous studies showed that a novel N-arylpyridone compound named AKEX0011 exhibited anti-inflammatory...

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Detalles Bibliográficos
Autores principales: Fan, Mingming, Xiao, Huijuan, Song, Dingyun, Zhu, Lili, Zhang, Jie, Zhang, Xinran, Wang, Jing, Dai, Huaping, Wang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983992/
https://www.ncbi.nlm.nih.gov/pubmed/35401236
http://dx.doi.org/10.3389/fphar.2022.848435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983992/
https://www.ncbi.nlm.nih.gov/pubmed/35401236
http://dx.doi.org/10.3389/fphar.2022.848435

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