Painful Diabetic Neuropathy Is Associated with Compromised Microglial IGF-1 Signaling Which Can Be Rescued by Green Tea Polyphenol EGCG in Mice

BACKGROUND: Painful diabetic neuropathy (PDN) is a frequent and troublesome complication of diabetes, with little effective treatment. PDN is characterized by specific spinal microglia-mediated neuroinflammation. Insulin-like growth factor 1 (IGF-1) primarily derives from microglia in the brain and...

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Detalles Bibliográficos
Autores principales: Chen, Xin, Le, Yue, Tang, Si-Qi, He, Wan-you, He, Jian, Wang, Yun-hua, Wang, Han-bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984065/
https://www.ncbi.nlm.nih.gov/pubmed/35401920
http://dx.doi.org/10.1155/2022/6773662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984065/
https://www.ncbi.nlm.nih.gov/pubmed/35401920
http://dx.doi.org/10.1155/2022/6773662

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