Cargando…
The Age-Driven Decline in Neutrophil Function Contributes to the Reduced Efficacy of the Pneumococcal Conjugate Vaccine in Old Hosts
Despite the availability of vaccines, Streptococcus pneumoniae (pneumococcus) remains a serious cause of infections in the elderly. The efficacy of anti-pneumococcal vaccines declines with age. While age-driven changes in antibody responses are well defined, less is known about the role of innate im...
Autores principales: | Simmons, Shaunna R., Tchalla, Essi Y. I., Bhalla, Manmeet, Bou Ghanem, Elsa N. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984502/ https://www.ncbi.nlm.nih.gov/pubmed/35402289 http://dx.doi.org/10.3389/fcimb.2022.849224 |
Ejemplares similares
-
Extracellular adenosine signaling reverses the age‐driven decline in the ability of neutrophils to kill Streptococcus pneumoniae
por: Bhalla, Manmeet, et al.
Publicado: (2020) -
Liposomal Encapsulation of Polysaccharides (LEPS) as an Effective Vaccine Strategy to Protect Aged Hosts Against S. pneumoniae Infection
por: Bhalla, Manmeet, et al.
Publicado: (2021) -
Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine receptor signaling
por: Herring, Sydney E., et al.
Publicado: (2022) -
The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia
por: Domon, Hisanori, et al.
Publicado: (2021) -
Neutrophil Recruitment in Pneumococcal Pneumonia
por: Palmer, Catherine S., et al.
Publicado: (2022)