The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation

Planar chiral [2.2]paracyclophanes are resolved through the direct C–H arylation of enantiopure oxazolines, providing a convenient route to ligands and chiral materials. Preliminary results show that hydrolysis followed by decarboxylative phosphorylation leads to enantiopure [2.2]paracyclophane deri...

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Detalles Bibliográficos
Autores principales: Tewari, Shashank, Mungalpara, Maulik N., Patel, Suraj, Rowlands, Gareth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984818/
https://www.ncbi.nlm.nih.gov/pubmed/35424822
http://dx.doi.org/10.1039/d2ra01075e
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author Tewari, Shashank
Mungalpara, Maulik N.
Patel, Suraj
Rowlands, Gareth J.
author_facet Tewari, Shashank
Mungalpara, Maulik N.
Patel, Suraj
Rowlands, Gareth J.
author_sort Tewari, Shashank
collection PubMed
description Planar chiral [2.2]paracyclophanes are resolved through the direct C–H arylation of enantiopure oxazolines, providing a convenient route to ligands and chiral materials. Preliminary results show that hydrolysis followed by decarboxylative phosphorylation leads to enantiopure [2.2]paracyclophane derivatives that are otherwise challenging to prepare.
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spelling pubmed-89848182022-04-13 The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation Tewari, Shashank Mungalpara, Maulik N. Patel, Suraj Rowlands, Gareth J. RSC Adv Chemistry Planar chiral [2.2]paracyclophanes are resolved through the direct C–H arylation of enantiopure oxazolines, providing a convenient route to ligands and chiral materials. Preliminary results show that hydrolysis followed by decarboxylative phosphorylation leads to enantiopure [2.2]paracyclophane derivatives that are otherwise challenging to prepare. The Royal Society of Chemistry 2022-03-17 /pmc/articles/PMC8984818/ /pubmed/35424822 http://dx.doi.org/10.1039/d2ra01075e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tewari, Shashank
Mungalpara, Maulik N.
Patel, Suraj
Rowlands, Gareth J.
The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation
title The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation
title_full The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation
title_fullStr The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation
title_full_unstemmed The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation
title_short The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation
title_sort concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by c–h activation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8984818/
https://www.ncbi.nlm.nih.gov/pubmed/35424822
http://dx.doi.org/10.1039/d2ra01075e
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